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Education
Ph.D. Statistical Genetics
Vanderbilt University
2004
M.S. Applied Statistics
Vanderbilt University
2002
B.S. Biology
University of Pittsburgh, Johnstown
1999
Honors, Awards, and Patents
2000-2002 NIH Breast Cancer Research Training Grant
2001 Vanderbilt University, Charles R. Park Student Travel Award
2002-2003 NLM Bioinformatics Research Training Grant
2002 Vanderbilt University Graduate School Travel Grant
2003 Vanderbilt University Dissertation Enhancement Grant
2002 U.S. Provisional Patent: Method and Apparatus for Multifactor Dimensionality Reduction
2003 U.S. Patent Pending: Method and Apparatus for Multifactor Dimensionality Reduction
2003 Vanderbilt University Graduate School Travel Grant
2003 Vanderbilt University, Charles R. Park Student Travel Award
Memberships in Professional Societies
American Statistical Association (ASA)
American Society of Human Genetics (ASHG)
International Neural Network Society (INNS)
International Genetic Epidemiology Society (IGES)
International Society for Genetic and Evolutionary Computation (ISGEC)
International Society for Computational Biology (ISCB)
Research Interests
Statistical Genetics
Genetic Epidemiology
Bioinformatics
Computational Biology
Cancer
Cardiovascular Disease
Hypertension
Schizophrenia
Diabetes
Pharmacogenetics
Microarray Analysis
Proteomics
Evolutionary Computation
Epistasis
Publications
Peer-Reviewed Papers
Ritchie, M.D., Hahn, L.W., Roodi, N., Bailey, L.R., Dupont, W.D., Plummer, W.D., Parl, F.F. and Moore, J.H. Multifactor Dimensionality Reduction Reveals High-Order Interactions among Estrogen Metabolism Genes in Sporadic Breast Cancer. American Journal of Human Genetics, 69:138-147. (2001) (PubMed)
Moore J.H., Hahn L.W., Ritchie M.D., Thornton T.A., White B.C. Application of genetic algorithms to the discovery of complex genetic models for simulation studies in human genetics. In: Langdon WB, Cantu-Paz E, Mathias K, Roy R, Davis D, Poli R, Balakrishnan K, Honavar V, Rudolph G, Wegener J, Bull L, Potter MA, Schultz AC, Miller JF, Burke E, and Jonoska N, eds. Proceedings of the Genetic and Evolutionary Computation Conference, Morgan Kaufmann Publishers, San Francisco, pp. 1150-55. (2002)
Donaldson, J.C., Dise, R.S., Ritchie, M.D. and Hanks, S.K. Nephrocystin conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity. Journal of Biological Chemistry, 277, 29028-29035. (2002) (PubMed)
Hahn, L.W., Ritchie, M.D., and Moore, J.H. Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics, 19, 376-382. (2003) (PubMed)
Ritchie, M.D., Hahn, L.W. and Moore, J.H. Power of multifactor dimensionality reduction for detecting gene-gene and gene-environment interactions. Genetic Epidemiology, 24, 150-157. (2003) (PubMed)
Moore, J.H., Thornton, T.A., Ritchie, M.D. Basic statistics. In: Dracopoli, N.C., Haines, J.L., Korf, B.R., Moir, D.T., Morton, C.C., Seidman, C.E., Seidman, J.G., Smith, D.R. (eds), Current Protocols in Human Genetics, Wiley-Liss, Inc., New York, pp. A.3M.1-A.3M.10 (2003).
Ritchie, M.D., White, B., Parker, J.S., Hahn, L.W., and Moore, J.H. Optimization of neural network architecture improves the power to identify gene-gene interaction in common diseases. BMC Bioinformatics, 4:28 (2003). (PubMed)
Moore, J.H., Hahn, L.W., Ritchie, M.D., Thornton, T.A., White, B. Routine Discovery of High-Order Epistasis Models for Computational Studies in Human Genetics. Applied Soft Computing, 4: 79-86 (2004).
Cho,Y.M., Ritchie, M.D., Moore, J.H., Moon, M.K., Lee, Y.Y, Yoon, K.H., Sung, Y.A., Lang, H.C., Park, J.Y., Lee, K.U., Shin, H.D., Kim, S.Y., Lee, H.K., Park, K.S. Multifactor Dimensionality Reduction Reveals a Two-Locus Interaction Associated with Type 2 Diabetes Mellitus. Diabetologia,47: 549-554 (2004). (PubMed)
Tsai, C.T., Lai, L.P., Chiang, F.T., Fallin, D., Hwang, J.J., Ritchie, M.D., Moore, J.H., Hsu, K.L., Tseng, C.D., Liau, C.S., Lin, J.L., Tseng, Y.Z. Renin-Angiotensin System Gene Polymorphisms and Atrial Fibrillation. Circulation, 109: 1640-1646 (2004). (PubMed)
Williams, S.M., Ritchie, M.D., Phillips, J.A., Wong, L.-J., Felder, R.A., Jose, P.A., Moore, J.H. Identification of multilocus genotypes that associate with high-risk and low-risk of hypertension, Human Heredity, 57:28-38 (2004). (PubMed)
Coffey, C.S., Hebert, P.R., Ritchie, M.D., Krumholz, H.M., Morgan, T.M., Gaziano, J.M., Ridker, P.M., and Moore, J.H. An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: The importance of model validation. BMC Bioinformatics, 5:49 (2004). (PubMed)
Ritchie, M.D., Coffey, C.S., and Moore J.H. Genetic Programming Neural Networks: A Bioinformatics Tool for Human Genetics. Lecture Notes in Computer Science, 3102: 438-448 (2004).
Shin, N. Dise, R.S., Schneider-Mergener, J., Ritchie, M.D., Kilkenny, D.M., Hanks, S.K. Partial Subsets of the Major CAS Substrate Domain Sites of Tyrosine Phosphorylation are Sufficient to Promote Cell Migration. Journal of Biological Chemistry, 279(37): 38331-38337 (2004). (PubMed)
Vanhoose A.M., Ritchie M.D., Winder D.G. Regulation of cAMP levels in area CA1 of hippocampus by Gi/o-coupled receptors is stimulus dependent in mice. Neuroscience Letters 370(1):80-3 (2004). (PubMed)
Soares, M.L., Coelho, T., Sousa, A., Ritchie, M.D., Williams, S.M., Batalov, S., Conceição, I., de Lurdes, M., Luís, S., Saraiva , M.J., Buxbaum, J.N. Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease. Human Molecular Genetics, 2005 Feb 15;14(4):543-53. (PubMed)
Bush WS, Motsinger AA, Dudek, SM, Ritchie MD. Can neural network constraints in GP provide power to detect genes associated with human disease? Lecture Notes in Computer Science, 3449:44-53 (2005).
Hulgan T, Haas DW, Haines JL, Ritchie MD, Robbins GK, Shafer RW, Clifford DB, Kallianpur A, Summar M, Canter JA. Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study. AIDS, 19(13):1341-1349 (2005). (PubMed)
Ma DQ, Whitehead PL, Menold MM, Martin ER, Ashley-Koch AE, Mei H, Ritchie MD, DeLong GR, Abramson RK, Wright HH, Cuccaro ML, Hussman JP, Gilbert JR, Pericak-Vance MA. Identification of significant association and gene-gene interaction on GABA receptor subunit genes in Autism. American Journal of Human Genetics, 77(3):377-88 (2005). (PubMed)
Martin ER, Ritchie MD, Kang S, Hahn L, Moore JH. A novel method to identify potential interactions in nuclear families: The MDR-PDT. Genetic Epidemiology, 30:111-23 (2006). (PubMed)
Takahashi H, Wilkinson GR, PhD, Nutescu EA, Morita T, Ritchie MD, Scordo MG, Pengo V, Barban M, Padrini R, Ieiri I, Otsubo K, Kashima T, Kimura S, Kijima S, Echizen H. Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African Americans. Pharmacogenetics and Genomics, 16:101-110 (2006). (PubMed)
Ashley-Koch A, Mei H, Jaworski J, Ma D, Ritchie MD, Menold M, Abramson R, Wright H, Cuccaro M, Gilbert J, Martin E, Pericak-Vance M. An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for Autistic disorder. Annals of Human Genetics, 70:281-92 (2006). (PubMed)
Motsinger AA, Lee SL, Mellick G, Ritchie MD. Power of genetic programming neural networks for detecting high-order gene-gene interactions in association studies of human disease and an application in ParkinsonÕs disease. BMC Bioinformatics, 7:39 (2006). (PubMed)
Motsinger AA, Donahue BS, Brown NJ, Roden DM, Ritchie MD. Risk factor interactions and genetic effects associated with post-operative Atrial Fibrillation. Pacific Symposium on Biocomputing Proceedings, 11:584-595 (2006). (PubMed)
Dudek SM, Motsinger AA, Velez DR, Williams SM, Ritchie MD. Data simulation software for whole-genome association studies and other studies in human genetics. Pacific Symposium on Biocomputing Proceedings, 11:499-510 (2006). (PubMed)
Sanada H, Yatabe J, Midorikawa S, Hashimoto S, Watanabe T, Moore JH, Ritchie MD, Williams SM, Pezzullo JC, Eisner GM, Jose PA, Felder RA. Salt sensitivity and G-protein-coupled receptor kinase type 4 polymorphisms. Clinical Chemistry, 52:352-60 (2006). (PubMed)
Motsinger AA, Ritchie MD. Multifactor Dimensionality Reduction: an analysis strategy for modeling and detecting gene-gene interactions in human genetics and pharmacogenomics studies. Human Genomics, 2:318-328. (2006) (PubMed)
Brassat D, Motsinger AA, Walker K, Steiner LL, Erlich HA, Barcellos L, Pericak-Vance MA, Hauser SL, Haines JL, Oksenberg JR, Ritchie MD. Multifactor dimensionality reduction reveals gene-gene interactions associated with Multiple Sclerosis in African Americans. Genes and Immunity, 7:310-315 (2006). (PubMed)
Motsinger AA, Dudek SM, Hahn LW, Ritchie MD. Comparison of neural network optimization approaches for studies of human genetics. Lecture Notes in Computer Science, 3907:103-114 (2006).
Motsinger AA, Ritchie MD, Dobrin SE. Clinical applications of whole-genome association studies (WGAS): future applications at the bedside. Expert Reviews in Molecular Diagnostics, 6:551-65 (2006). (PubMed)
Motsinger AA, Hahn LW, Dudek SM, Ryckman KK, Ritchie MD. Alternative cross-over strategies and selection techniques for grammatical evolution optimized neural networks. Proceedings of Genetic and Evolutionary Computation Conference, Association for Machine Learning Press, New York, 947-949 (2006).
Kallianpur AR, Hulgan T, Canter JA, Ritchie MD, Haines JL, Robbins GK, Shafer RW, Clifford DB, Haas DW. Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy: an AIDS clinical trials group study. AIDS, 20:1503-1513 (2006). (PubMed)
Motsinger AA, Ritchie MD. The effect of alternative cross-validation strategies on the performance of Multifactor Dimensionality Reduction. Genetic Epidemiology, 30: 546-555 (2006). (PubMed)
Haas DW, Geraghty DE, Andersen J, Mar J, Motsinger AA, D'Aquila RT, Unutmaz D, Benson CA, Ritchie MD, Landay A. Immunogenetics of CD4 lymphocyte recovery during antiretroviral therapy: an AIDS clinical trials group study. Journal of Infectious Disease, 198:1098-1107 (2006). (PubMed)
Motsinger AA, Ritchie MD, Shafer RW, Robbins GK, Morse GD, LabbŽ L, Wilkinson GR, Clifford DB, D'Aquila RT, Johnson VA, De Gruttola V, Pollard RB, Merigan TC, Hirsch MS, Donahue JP, Kim RB, Haas DW. Multilocus gene-gene interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study. Pharmacogenetics and Genomics, 16:837-845 (2006). (PubMed)
Ritchie MD, Haas DW, Motsinger AA, Donahue JP, Erdem H, Raffanti S, Rebiero P, George AL, Kim RB, Haines JL, Sterling TR. Drug transporter and metabolizing enzyme gene variants and non-nucleoside reverse transcriptase inhibitor hepatotoxicity. Clinical Infectious Diseases, 43:779-82 (2006). (PubMed)
Bush WS, Dudek SM, Ritchie MD. Parallel Multifactor Dimensionality Reduction: a tool for the large scale analysis of gene-gene interactions. Bioinformatics, 22:2173-4 (2006). (PubMed)
Crooke PS, Ritchie MD, Hachey DL, Dawling S, Roodi N, Parl FF. Estrogens, enzyme variants, and Breast Cancer. A risk model. Cancer. Cancer, Epidemiology, Biomarkers, and Prevention, 15:1620-9 (2006). (PubMed)
Tsai CT, Hwang JJ, Ritchie MD, Moore JH, Fallin D, Chiang FT, Lai LP, Hwang JJ, Hsu KL, Tseng CD, Liau CS, Lin JL, Tseng YZ. Renin-angiotensin system gene polymorphisms and Coronary Artery disease in a large angiographic cohort: detection of high-order gene-gene interaction. Atherosclerosis, 195(1):172-80 (2007). (PubMed)
Motsinger AA, Reif DM, Dudek SM, Ritchie MD. Dissecting the evolutionary process of grammatical evolution optimized neural networks. IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, 1-8 (2006).
Motsinger AA ,Brassat D, Caillier SC, Erlich HA, Walker K, Steiner LL, Barcellos L, Pericak-Vance MA, Schmidt S, Gregory S, Hauser SL, Haines JL, Oksenberg JR, Ritchie MD. Complex gene-gene interactions in Multiple Sclerosis: a multi-factorial approach reveals associations with inflammatory genes. Neurogenetics, 8:11-20 (2007). (PubMed)
Nordgard SH, Ritchie MD, Motsinger AA, Lemmon G, Fjelstad S, Aln¾s GIG, Jensrud SD, Berg M, Geisler S, Moore JH, L¿nning PE, B¿rresen-Dale AL, Kristensen VN. Polymorphisms in the ABCB1 and the GST genes in relation to P53 mutation and treatment response to doxorubicin in Breast Cancer patients. Pharmacogenetics and Genomics, 17:127-36 (2007). (PubMed)
Canter JA, Summar ML, Smith HB, Ritchie MD, Motsinger AA, Christian K, Drinkwater D, Dyer KL, Kavanaugh A, Barr FE. The carbamyl-phosphate synthase I T1405N polymorphism is associated with increased pulmonary artery pressure in children following surgical repair of congenital heart defects: a validated genetic association study. Mitochondrion, 7:204-210 (2007). (PubMed)
Velez DR, White BC, Motsinger AA, Bush WS, Ritchie MD, Williams SM, Moore JH. A balanced accuracy metric for epistasis modeling in imbalanced datasets using Multifactor Dimensionality Reduction. Genetic Epidemiology, 31:306-315 (2007). (PubMed)
Motsinger AA, Reif DM, Fanelli TJ, Davis AC, Ritchie MD. Linkage disequilibrium in genetic association studies improves the performance of grammatical evolution neural networks. IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, 1-8 (2007).
Bush WS, Thornton-Wells TA, Ritchie MD. Association rule discovery has the ability to model complex genetic effects. Proceedings of the 2007 IEEE Symposium on Computational Intelligence and Data Mining, 624-629 (2007).
Ritchie MD, Motsinger AA, Bush WS, Coffey CS, Moore JH. Genetic programming neural networks: a powerful bioinformatics tool for human genetics. Applied Soft Computing, 7:471-479 (2007).
Ashley-Koch AE, Jaworski J, Ma D, Mei H, Ritchie MD, Skaar DA, Delong GR, Abramson RK, Wright HH, Cuccaro ML, Gilbert JR, Martin ER, Pericak-Vance MA. Investigation of potential gene-gene interactions between APOE and RELN contributing to Autism risk. Psychiatric Genetics, 17:221-226 (2007). (PubMed)
Darbar D, Motsinger AA, Ritchie MD, Gainer JV, Roden DM. Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone Atrial Fibrillation. Heart Rhythm, 4:743-749 (2007). (PubMed)
Ritchie MD, Bartlett J, Bush WS, Edwards TL, Motsinger AA, Torstenson ES. Exploring epistasis in candidate genes for Rheumatoid Arthritis. BMC Proceedings, 1 Suppl 1:S70 (2007). (PubMed)
Bartlett CW, Vieland VJ, Bartlett J, Bell JT, Bhattacharjee S, Clerget-Darpoux F, Bush WS, Edwards TL, Gao G, Halder I, Huang Y, Kotti S, Larkin EK, Li H, Motsinger AA, Mukhopadhyay N, Namkung J, Park T, Ritchie MD, Stein CM, Zhou JY. Discussing gene-gene interaction: warning--translating equations to English may result in jabberwocky. Genetic Epidemiology, 31 Suppl 1:S61-7 (2007). (PubMed)
Pretorius MM, Gainer JV, Van Guilder GP, Coelho EB, Luther JM, Fong P, Rosenbaum DD, Malave HA, Yu C, Ritchie MD, Vaughan DE, Brown NJ. The Bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance. Clinical Pharmacology and Therapeutics, 83(1):122-9 (2008). (PubMed)
Canter JA, Haas DW, Kallianpur AR, Ritchie MD, Robbins GK, Shafer RW, Murdock DG, Hulgan T. The mitochondrial pharmacogenomics of haplogroup T: MTND2(*)LHON4917G and antiretroviral therapy-associated peripheral neuropathy. Pharmacogenomics Journal, 8(1):71-7 (2008). (PubMed)
Schwartz UI, Ritchie MD, Bradford Y, Dudek S, Frye-Anderson A, Kim RB, Roden DM, Stein CM. Genetic determinants of response to warfarin during initial anticoagulation. NEJM, 358(10):999-1008 (2008). (PubMed)
Edwards TL, Bush WS, Turner SD, Dudek SM, Torstenson ES, Schmidt M, Martin E, Ritchie MD. Generating linkage disequilibrium patterns in data simulations using genomeSIMLA. Lecture Notes in Computer Science, 4973: 24-35 (2008).
Darbar D, Kimbrough J, Jawaid A, McCray R, Ritchie MD, Roden DM. Persistent atrial fibrillation is associated with reduced risk of torsades de pointes in patients with drug-induced long QT syndrome. J Am Coll Cardiol, 51(8):836-42 (2008). (PubMed)
Motsinger-Reif AA, Dudek SM, Hahn LW, Ritchie MD. Comparison of approaches for machine learning optimization of neural networks for detecting gene-gene interactions in genetic epidemiology. Genetic Epidemiology, 32(4):325-40 (2008). (PubMed)
Motsinger-Reif AA, Reif DM, Fanelli TJ, Ritchie MD. A comparison of analytical methods for genetic association studies. Genetic Epidemiology, 32(8):767-78 (2008). (PubMed)
Bush WS, Edwards TL, Dudek SM, McKinney BA, Ritchie MD. Alternative contingency table measures improves the power and detection of Multifactor Dimensionality Reduction. BMC Bioinformatics, 9:238 (2008). (PubMed)
Cooper GM, Johnson JA, Langaee TY, Feng H, Stanaway IB, Schwartz U, Ritchie MD, Stein CM, Roden DM, Smith JD, Veenstra DL, Rettie AE, Rieder MJ. A Whole-Genome Scan for Common Genetic Variants with a Large Influence on Warfarin Maintenance Dose. Blood, 112:1022-7 (2008). (PubMed)
Edwards TL, Lewis KG, Velez DR, Dudek SM, Ritchie MD. Exploring the Performance of Multifactor Dimensionality Reduction in Large Scale SNP Studies and in the Presence of Genetic Heterogeneity among Epistatic Disease Models. Human Heredity, 67(3):183-92 (2008). (PubMed)
Motsinger-Reif AA, Fanelli TJ, Davis AC, Ritchie MD. Power of grammatical evolution neural networks to detect gene-gene interactions in the presence of error. BMC Research Notes, 1:65 (2008). (PubMed)
Edwards TL, Wang X, Chen Q, Wormly B, Riley B, OÕNeill FA, Walsh D, Ritchie MD, Kendler KS, Chen X. Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. Schizophrenia Research, 106(2-3); 208-17 (2008). (PubMed)
Li C, Schwartz UI, Ritchie MD, Roden DM, Stein CM, Kurnik D. Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy. Blood, Epub ahead of print (2008 Dec). (PubMed)
Edwards TL, Pericak-Vance M, Gilbert JR, Haines JL, Martin ER, Ritchie MD. An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics, 67(3):183-92 (2009). (PubMed)
Motsinger AA, Fanelli TJ, Dudek SM, Ritchie MD. Balanced accuracy as a fitness function in grammatical evolution neural networks is robust to imbalanced data. GECCO, in press (2009).
Bush WS, Dudek SM, Ritchie MD. Biofilter: a knowledge-integration system for the multi-locus analysis of genome-wide association studies. Pacific Symposium on Biocomputing, 368-79 (2009). (PubMed)
Body SC, Collard CD, Shernan SK, Fox AA, Liu KY, Ritchie MD, Perry TE, Muehlschlegel JD, Aranki S, Donahue BS, Pretorius M, Estrada J, Ellinor PT, Newton-Cheh C, Seidman CE, Seidman, Hermann DS, Lichtner P, Meitinger T, Pfeufer A, KŠŠb S, Brown NJ, Roden DM, Darbar D. Variation in the 4q25 Chromosomal Locus Predicts Atrial Fibrillation after Coronary Artery Bypass Graft Surgery. Circulation Genetics, in press.
Bush WS, Crawford DC, Alexander C, George A, Roden DM, Ritchie MD. Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias. Pharmacogenomics, 10(6):1043-53 (2009). (PubMed)
Papers Submitted
Edwards TL, Torstenson ES, Martin EM, Ritchie MD. A cross-validation procedure for general pedigrees and matched odds ratio fitness metric implemented for the multifactor dimensionality reduction pedigree disequilibrium test MDR-PDT and cross-validation: power studies. Genetic Epidemiology, submitted.
Ritchie MD, Denny JC, Crawford DC, Havens A, Weiner J, Pulley JM, Basford M, Balser JR, Masys DR, Haines JL, Roden DM. Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. JAMA, submitted.
Edwards TL, Turner SD, Torstenson ES, Dudek SM, Martin EM, Ritchie MD. A general framework for formal tests of interaction after exhaustive search methods with applications to MDR and MDR-PDT. PLOS Computational One, submitted.
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