MDR-PDT is currently open to the public for beta testing and review, by request only.
If you wish to participate in the testing of the software, please submit a request to the following address. Participants will receive the application via email as well as periodic notices when updates have been made in response to user's suggestions and issues.
Requirements:
The Ritchie Lab uses Linux to run most of their analyses. Therefore, MDR-PDT is developed on and for Linux. The code should compile on any system with GCC and with the libraries below installed, however, we do not have the capacity to support issues associated with compiling on alternate platforms.
MDR-PDT was compiled on RedHat Linux gcc version 3.3. Any recent version of RedHat with gcc-compat libraries installed should be able to run the application that without any difficulty.
Others using a different distribution will have to compile it on their own machines. The following free libraries are required to compile MDR-PDT:
As well as the standard library (installed by default on most Linux distributions)
Select relevant literature:
Martin ER, Bass MP, Gilbert JR, Pericak-Vance MA, Hauser ER. (2003) Genotype-based association test for general pedigrees: the genotype-PDT. Genet Epidemiol. Nov;25(3):203-13.
Ritchie MD, Hahn LW, Moore JH (2003) Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol. Feb;24(2):150-7.
Hahn LW, Ritchie MD, Moore JH. (2003). Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics. Feb 12;19(3):376-82.
Related Links:
MDR-PDT - This is a new hybrid method which is merging the strengths of MDR (multifactor dimensionality reduction) and genotype-PDT (genotype pedigree disequilibrium test ). One of the major strengths of MDR is the ability to detect gene-gene and gene-environment interactions even when the main effects are absent. One of the major strengths of genotype-PDT is the ability to carry out single-locus linkage disequilibrium tests on extended pedigrees. However, MDR cannot be used on pedigree data and genotype-PDT is not effective at detecting interactions without main effects. The new hybrid method, MDR-PDT, can be used to examine pedigrees for gene-gene and gene-environment interactions.
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